Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DIAD, diisopropylazodicarboxylate; DMF, dimethylformamide; CDI, carbonyldiimidazole; met. lia., metabolic liability; MC, methylcellulose; ND, not determined; PK, pharmacokinetic; PyBroP, bromo
مقالات ISI DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene (ترجمه نشده)
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Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Ar, aryl; ATP, Adenosine-5′-triphosphate; AUC, area under the curve; BA, bioavailability; CYP, Cytochrome P450; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DIPEA, diisopropylethylamine; Δ, heat; DME, 1,2-dimethoxyethane; DMF, N,N-dimeth
1-/2-/3-Fluoroalkyl-substituted indoles, promising medicinally and biologically beneficial compounds: Synthetic routes, significance and potential applications
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; AIBN, azobisisobutyronitrile; bipy, 2,2′-bipyridine; Boc, tert-butoxycarbonyl; ButTMG, 2-tert-butyl-1,1,3,3-tetramethylguanidine; CCR5, C-C chemokine receptor type 5; CPI, cyclopropapyrroloindole; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DIPEA, diisopropy
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DMAP, 4-dimethylaminopyridine; DMPC/DMPG, 1,2-dimyristoyl-sn-glycero-3-phospocholine/1,2-dimyristoyl-sn-glycero-3-phosphoglycerol; Erk1/2, extracellular signal-regulated kinases 1 and 2; LiHMDS, lithium hexamethyld
Monovalent mannose-based DC-SIGN antagonists: Targeting the hydrophobic groove of the receptor
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Anti-infectives; Carbohydrates; DC-SIGN; DC-SIGN antagonists; Glycomimetics; LectinsCRD, carbohydrate recognition domain; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DC, dendritic cell; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-3-grabb
Synthesis and photoreactivity of α-diketone-type precursors of acenes and their use in organic-device fabrication
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; AFM, atomic force microscopy; BHJ, bulk heterojunction; CIS, configuration interaction singles; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCB, o-dichlorobenzene; DIBAL, diisobutylaluminium hydride; DDQ, 2,3-dichloro-5,6-dicyanobenzoquinone; DFT, density fu
Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Abu, amino-butyric acid; ACN, acetonitrile; Boc, tert-butyloxycarbonyl; CI, 95% Confidence Interval; Dab, diaminobutyric acid; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DIC, N,N-diisopropylcarbodiimide; DIPEA, N,N-diisopropylethylamin
Synthesis of conformationally constrained γ-d-glutamyl-meso-diaminopimelic acid derivatives as ligands of nucleotide-binding oligomerization domain protein 1 (Nod1)
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Nod1; Immunomodulator; γ-d-Glutamyl-meso-diaminopimelic acid; NF-κB activation; Immunotoxicity; ImmunostimulantC12-iE-DAP, lauroyl-γ-d-glutamyl-meso-diaminopimelic; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; iE-DAP, γ-d-glutamyl-meso-diaminopimelic acid; IL
Cyclic triphosphenium ions and related species
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; biphep, 2,2′-bis(diphenylphosphino)-1,1′-biphenyl; CTI, cyclic triphosphenium ion; Cy, cyclo-hexyl; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; dcypm, bis(dicyclohexylphosphino)methane; dcypp, 1,3-bis(dicyclohexylphosphino)propane; dedppe, (1-diethylphosphin
Cationic substrates of soybean lipoxygenase-1
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; BSTFA, N,O-bis(trimethylsilyl)trifluoroacetamide; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; EIMS, electron-impact mass spectrometry; ESI-MS, electrospray ionization mass spectrometry; GC/MS, gas chromatography/mass spectrometry; 13-HOD, 13(S)-hydroxy-9(Z),
Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Toll-like receptor; TLR7; TLR8; Imidazoquinoline; NOESY; HIV; Autoimmune diseasesCD, cluster of differentiation; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DMAP, 4-dimethylaminopyridine; DMF, N,N-dimethylformamide; ESI-TOF, electrospray ionization-time of f
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; 5-FU, 5-fluorouracil; Ac, acetyl; ATCC, American Type Culture Collection; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloro methane; DMAP, 4-dimetylaminopyridine; DMEM, Dulbecco's Modified Eagle's Medium; DMF, dimethylformamide; DMSO, dimethylsulfoxi
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Benzylidene-10H-anthracen-9-ones; 10-(2-Oxo-2-phenylethylidene)-10H-anthracen-9-ones; Tubulin; Antiproliferative; Antimitotic; ColchicineADR, adriamycine; CSI, colchicine site inhibitor; DBU, 1,8-Diazabicyclo[5.4.0]undec-7-ene; ITP, inhibition of tubulin
Synthesis of fluorofurans and perfluoroalkylfurans
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Organofluorine chemistry; Fluorofurans synthesis; Perfluoroalkylfurans; Trifluoromethylfurans; FluoroalkylfuransAc, acetyl; Acac, acetyl acetone; Bn, benzyl; Bz, benzoyl; mCPBA, mchloroperbenzoic acid; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCE, 1,2-dic
Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; AMD, age-related macular degeneration; BSA, bovine serum albumin; CEP, carboxyethylpyrrole; CEPH, 6-(2-carboxyethyl-1-pyrrolyl)-hexanoyl; COA, chicken ovalbumin; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DHA, docosahexaenoic acid; DMF, N,N-dimethylformamid
Steric and Electrostatic Effects at the C2 Atom Substituent Influence Replication and Miscoding of the DNA Deamination Product Deoxyxanthosine and Analogs by DNA Polymerases
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; 2-BrdI, 2-bromo-2′-deoxyinosine; CD, circular dichroism; CID, collision-induced dissociation; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; Dpo4, S. solfataricus P2 DNA polymerase IV; 2-FdI, 2-fluoro-2′-deoxyinosine; HMBC, heteronuclear multiple bond coherence
Functional studies of rat hydroxymethylbilane synthase
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Hydroxymethylbilane synthase; HMB synthase; Porphobilinogen deaminase; PBG deaminase; Porphobilinogen; Tetrapyrrole; Acute intermittent porphyriaAIP, acute intermittent porphyria; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; CTAOH, cetyltrimethylammonium hydr
Cellular inactivation and antitumor efficacy of a new zinc phthalocyanine with potential use in photodynamic therapy
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; PDT, photodynamic therapy; Pc, phthalocyanine; PS, photosensitizer; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DMPC, l-α-dimyristoyl-phosphatidylcholine; DPPEc, d,l-α-dipalmitoyl phosphatidylethanolamine containing cholesterol; PBS, phosphate-buffered salin
Hetero-arrays of porphyrins and phthalocyanines
Keywords: DBU، 1،8-دیازیبسیکلو [5.4.0] undec-7-ene; Porphyrins; Phthalocyanines; Supramolecular complexes; Electron transfer; Energy transferacac, acetylacetonate; AQ, substituted anthraquinone; dba, dibenzylideneacetone; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DDQ, 2,3-dichloro-5,6-dicyano-p-benzoquinone